ADAM15 Recombinant Rabbit Monoclonal Antibody [JE39-01] (HA722402)

UNIPROT #

Q13444

PROTEIN NAME

ADAM15

SYNONYMS

A disintegrin and metalloproteinase domain 15 (metargidin) antibody;A disintegrin and metalloproteinase domain 15 antibody;ADA15_HUMAN antibody;ADAM 15 antibody;ADAM metallopeptidase domain 15 antibody;Adam15 antibody;and cysteine-rich protein 15 antibody;Disintegrin and metalloproteinase domain-containing protein 15 antibody;disintegrin-like antibody;EC 3.4.24. antibody;MDC 15 antibody;MDC-15 antibody;MDC15 antibody;Metalloprotease RGD disintegrin protein antibody;Metalloproteinase like disintegrin like and cysteine rich protein 15 antibody;Metalloproteinase-like antibody;Metargidin antibody

SUBCELLULAR LOCATION

Endomembrane system, Cell junction, adherens junction, Cell projection, cilium, flagellum, Cytoplasmic vesicle, secretory vesicle, acrosome.

FUNCTION

Disintegrin and metalloproteinase domain-containing protein 15 is an enzyme that in humans is encoded by the ADAM15 gene. The protein encoded by this gene is a member of the ADAM (a disintegrin and metalloproteinase) protein family. ADAM family members are type I transmembrane glycoproteins known to be involved in cell adhesion and proteolytic ectodomain processing of cytokines and adhesion molecules. This protein contains multiple functional domains including a zinc-binding metalloprotease domain, a disintegrin-like domain, as well as an EGF-like domain. Through its disintegrin-like domain, this protein specifically interacts with the integrin beta chain, beta 3. It also interacts with Src family protein-tyrosine kinases in a phosphorylation-dependent manner, suggesting that this protein may function in cell-cell adhesion as well as in cellular signaling. Multiple alternatively spliced transcript variants encoding distinct isoforms have been observed.