ACY1 Recombinant Mouse Monoclonal Antibody [15G2-R] (HA601236)

UNIPROT #

Q03154

PROTEIN NAME

ACY1

SYNONYMS

ACY 1 antibody;ACY-1 antibody;Acy1 antibody;ACY1_HUMAN antibody;ACY1D antibody;ACYLASE antibody;Acylase I antibody;Aminoacylase 1 antibody;Aminoacylase-1 antibody;EC 3.5.1.14 antibody;epididymis secretory protein Li 5 antibody;HEL-S-5 antibody;N acyl L amino acid amidohydrolase antibody;N-acyl-L-amino-acid amidohydrolase antibody;OTTHUMP00000212459 antibody;OTTHUMP00000212462 antibody;OTTHUMP00000212463 antibody;OTTHUMP00000212464 antibody;OTTHUMP00000212465 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aminoacylase is involved in the regulation of the urea cycle. N-acetyl-L-glutamate is an allosteric activator of carbamoyl phosphate synthetase, a crucial enzyme that commits NH4+ molecules to the urea cycle. The urea cycle gets rid of excess ammonia (NH4+) in the body, a process that must be up-regulated during times of increased protein catabolism, as amino acid breakdown produces large amounts of NH4+. When amino acid catabolism increases, N-Acetylglutamate synthase is up-regulated, producing more N-acetyl-L-glutamate, which up-regulates carbamoyl phosphate synthetase and allows it to dispose of the excess NH4+ from catabolism.Aminoacylase is up-regulated during times of nutrient deficit or starvation, causing N-acetyl-L-glutamate breakdown, which down-regulates carbamoyl phosphate synthetase and the rest of the urea cycle. This response is evolutionarily advantageous, since a nutrient deficit means there isn't as much NH4+ that needs to be disposed of and since the body wants to salvage as many amino acids as it can.