Lane 1: Rat kidney tissue lysate
Lane 2: Mouse kidney tissue lysate
Rabbit polyclonal primary
ACY-1 Rabbit Polyclonal Antibody (ER1803-75)
Recombinant protein within human acy-1 aa 50-250.
Rat kidney tissue, mouse kidney tissue, rat brain tissue, human liver cancer tissue, human kidney tissue, human small intestine tissue, mouse liver tissue.
Store at +4C after thawing. Aliquot store at -20C. Avoid repeated freeze / thaw cycles.
1*PBS (pH7.4), 0.2% BSA, 50% Glycerol. Preservative: 0.05% Sodium Azide.
Protein affinity purified.
ACY 1 antibody; ACY-1 antibody; Acy1 antibody; ACY1_HUMAN antibody; ACY1D antibody; ACYLASE antibody; Acylase I antibody; Aminoacylase 1 antibody; Aminoacylase-1 antibody; EC 184.108.40.206 antibody; epididymis secretory protein Li 5 antibody; HEL-S-5 antibody; N acyl L amino acid amidohydrolase antibody; N-acyl-L-amino-acid amidohydrolase antibody; OTTHUMP00000212459 antibody; OTTHUMP00000212462 antibody; OTTHUMP00000212463 antibody; OTTHUMP00000212464 antibody; OTTHUMP00000212465 antibody
Belongs to the peptidase M20A family.
Expression is highest in kidney, strong in brain and weaker in placenta and spleen.
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene.