ACY-1 Rabbit Polyclonal Antibody (ER1803-75)

UNIPROT #

Q03154

PROTEIN NAME

ACY-1

SYNONYMS

ACY 1 antibody;ACY-1 antibody;Acy1 antibody;ACY1_HUMAN antibody;ACY1D antibody;ACYLASE antibody;Acylase I antibody;Aminoacylase 1 antibody;Aminoacylase-1 antibody;EC 3.5.1.14 antibody;epididymis secretory protein Li 5 antibody;HEL-S-5 antibody;N acyl L amino acid amidohydrolase antibody;N-acyl-L-amino-acid amidohydrolase antibody;OTTHUMP00000212459 antibody;OTTHUMP00000212462 antibody;OTTHUMP00000212463 antibody;OTTHUMP00000212464 antibody;OTTHUMP00000212465 antibody

SEQUENCE SIMILARITIES

Belongs to the peptidase M20A family.

TISSUE SPECIFICITY

Expression is highest in kidney, strong in brain and weaker in placenta and spleen.

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene.