ACVR2B Mouse Monoclonal Antibody [A5H6] (HA600066)

UNIPROT #

Q13705

PROTEIN NAME

ACVR2B

SYNONYMS

Activin A receptor type IIB antibody;Activin receptor type 2B antibody;Activin receptor type IIB antibody;Activin receptor type-2B antibody;ActR IIB antibody;ACTR-IIB antibody;ActRIIB antibody;ACVR 2B antibody;ACVR2B antibody;AVR2B_HUMAN antibody;HTX4 antibody;MGC116908 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.