ACSL3 Mouse Monoclonal Antibody [A8F6] (HA601069)

UNIPROT #

O95573

PROTEIN NAME

ACSL3

SYNONYMS

ACS3 antibody;Acsl3 antibody;ACSL3_HUMAN antibody;Acyl CoA synthetase long chain family member 3 antibody;FACL3 antibody;Fatty acid Coenzyme A ligase long chain 3 antibody;LACS 3 antibody;LACS3 antibody;Lignoceroyl CoA synthase antibody;Long chain acyl CoA synthetase 3 antibody;Long chain fatty acid CoA ligase 3 antibody;Long-chain acyl-CoA synthetase 3 antibody;Long-chain-fatty-acid--CoA ligase 3 antibody;PRO2194 antibody

SUBCELLULAR LOCATION

Mitochondrion, Peroxisome, Endoplasmic reticulum.

FUNCTION

Acyl-CoA synthetases (ACSL) activates long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Required for the incorporation of fatty acids into phosphatidylcholine, the major phospholipid located on the surface of VLDL. Has mainly an anabolic role in energy metabolism. Mediates hepatic lipogenesis. Preferentially uses myristate, laurate, arachidonate and eicosapentaenoate as substrates. Both isoforms exhibit the same level of activity (By similarity). The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene.