ACRV1 Recombinant Rabbit Monoclonal Antibody [JE36-02] (HA722543)

UNIPROT #

P26436

PROTEIN NAME

ACRV1

SYNONYMS

Acrosomal protein SP 10 antibody;Acrosomal protein SP-10 antibody;Acrosomal vesicle protein 1 antibody;ACRV1 antibody;ASPX_HUMAN antibody;D11S4365 antibody;Msa63 antibody;SP 10 antibody;Sp10 antibody;SPACA2 antibody;Sperm protein 10 antibody

SUBCELLULAR LOCATION

Cytoplasmic vesicle, secretory vesicle, acrosome.

FUNCTION

Acrosomal protein SP-10 is a protein that in humans is encoded by the ACRV1 gene. This gene encodes a testis-specific, differentiation antigen, acrosomal vesicle protein 1, that arises within the acrosomal vesicle during spermatogenesis, and is associated with the acrosomal membranes and matrix of mature sperm. This gene consists of 4 exons and its alternative splicing generates multiple distinct transcripts, which encode protein isoforms ranging from 81 to 265 amino acids. The longest transcript is the most abundant, comprising 53-72% of the total acrosomal vesicle protein 1 messages; the second largest transcript comprises 15-32%; the third and the fourth largest transcripts account for 3.4-8.3% and 8.7-12.5%, respectively; and the remaining transcripts combined account for < 1% of the total acrosomal vesicle protein 1 message. It is suggested that phenomena of cryptic splicing and exon skipping occur within this gene. The acrosomal vesicle protein 1 may be involved in sperm-zona binding or penetration, and it is a potential contraceptive vaccine immunogen for humans.