Acetyl CoA synthetase Recombinant Rabbit Monoclonal Antibody [JF0917] (ET1702-21)

UNIPROT #

Q9NR19

PROTEIN NAME

Acetyl CoA synthetase

SYNONYMS

ACAS2 antibody;AceCS antibody;Acetate CoA ligase antibody;Acetate thiokinase antibody;Acetate--CoA ligase antibody;Acetyl CoA synthetase antibody;Acetyl Coenzyme A synthetase 2 (ADP forming) antibody;Acetyl coenzyme A synthetase cytoplasmic antibody;Acetyl-CoA synthetase antibody;Acetyl-coenzyme A synthetase antibody;ACS antibody;ACSA antibody;ACSA_HUMAN antibody;ACSS2 antibody;Acyl activating enzyme antibody;Acyl CoA synthetase short chain family member 2 antibody;Acyl-activating enzyme antibody;Acyl-CoA synthetase short-chain family member 2 antibody;Cytoplasmic acetyl coenzyme A synthetase antibody;cytoplasmic antibody;MYH7B antibody

SEQUENCE SIMILARITIES

Belongs to the ATP-dependent AMP-binding enzyme family.

POST-TRANSLATIONAL MODIFICATION

Reversibly acetylated at Lys-661 (By similarity). The acetyl-CoA synthase activity is inhibited by acetylation and activated by deacetylation mediated by the deacetylases SIRT1 and SIRT3 (By similarity).

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

ACSS2 (acyl-CoA synthetase short-chain family member 2), also known as ACAS2, ACS, ACSA or AceCS, is a 701 amino acid cytoplasmic protein that belongs to the ATP-dependent AMP-binding enzyme family. Existing as a monomer, ACSS2 functions to catalyze the ATP-dependent activation of acetate, a reaction that yields acetyl-CoA for use in energy generation and lipid synthesis. ACSS2 expression, which is highest in liver and kidney tissue, is regulated by the presence of unsaturated fatty acids and sterol regulatory element-binding proteins (SREBPs). Human ACSS2 exists as two alternatively spliced isoforms and shares 93% sequence identity with its mouse counterpart, suggesting a conserved role between species.