Lane 1: human lung tissue lysate
Lane 2: mouse kidney tissue lysate
Lane 3: human liver tissue lysate
Recombinant Rabbit monoclonal primary
ACE Recombinant Rabbit Monoclonal Antibody [JM59-32] (ET1705-36)
Synthetic peptide within human ace aa 1257-1306 / 1306.
Human lung tissue lysate, mouse kidney tissue lysate, human liver tissue lysate, human kidney tissue, mouse testis tissue, mouse kidney tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
ACE 1 antibody; ACE antibody; ACE T antibody; ACE_HUMAN antibody; ACE1 antibody; Angiotensin converting enzyme somatic isoform antibody; Angiotensin converting enzyme testis specific isoform antibody; Angiotensin I converting enzyme 1 antibody; Angiotensin I converting enzyme antibody; Angiotensin I converting enzyme peptidyl dipeptidase A 1 antibody; angiotensin I converting enzyme peptidyl-dipeptidase A 1 transcript antibody; Angiotensin-converting enzyme antibody; Carboxycathepsin antibody; CD 143 antibody; CD143 antibody; CD143 antigen antibody; DCP 1 antibody; DCP antibody; DCP1 antibody; Dipeptidyl carboxypeptidase 1 antibody; Dipeptidyl carboxypeptidase I antibody; Kininase II antibody; MGC26566 antibody; MVCD3 antibody; Peptidase P antibody; Peptidyl dipeptidase A antibody; soluble form antibody; Testicular ECA antibody
Belongs to the peptidase M2 family.
Ubiquitously expressed, with highest levels in lung, kidney, heart, gastrointestinal system and prostate. Isoform Testis-specific is expressed in spermatocytes and adult testis.
Phosphorylated by CK2 on Ser-1299; which allows membrane retention.
Secreted. Cell membrane. Cytoplasm.
Angiotensin-converting enzyme (ACE) is a carboxy-terminal dipeptidyl exo-peptidase that converts Angiotensin I to the potent vasopressive hormone, Angiotensin II. There are two isoforms of ACE, the pulmonary ACEP and the testicular ACET. ACEP is a glycoprotein expressed in vascular endothelial cells of the lung, liver, adrenal cortex, pancreas, kidney and spleen. The ACET isoform is expressed exclusively in adult testis by developing sperm cells, specifically, late pachytene spermatocytes. Additionally, ACE inactivates bradykinin, a vasodepressor peptide, and is involved in fluid/electrolyte homeostasis. Although it bears significant sequence homology to ACE, ACE2 shows a more restricted pattern of expression. ACE is expressed ubiquitously throughout the vasculature while ACE2 is expressed only in cardiac, renal and testicular cells.
Chen, Qiuhua et al.
Sini decoction ameliorates sepsis-induced acute lung injury via regulating ACE2-Ang (1-7)-Mas axis and inhibiting the MAPK signaling pathway. | Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie 
Chen, H., Yu, B., Guo, X......
Chen, H., Yu, B., Guo, X., Hua, H., Cui, F., Guan, Y., Tian, Y., Zhang, X., Zhang, Y., & Ma, H. (2021). Chronic Intermittent Hypobaric Hypoxia Decreases High Blood Pressure by Stabilizing the Vascular Renin-Angiotensin System in Spontaneously Hypertensive Rats. Frontiers in physiology, 12, 639454.
Liu, Junjun et al.
Sini decoction alleviates E. coli induced acute lung injury in mice via equilibrating ACE-AngII-AT1R and ACE2-Ang-(1-7)-Mas axis. | Life Sciences