ACADM Rabbit Polyclonal Antibody (ER1804-01)

UNIPROT #

P11310

PROTEIN NAME

ACADM

SYNONYMS

ACAD 1 antibody;ACAD1 antibody;Acadm antibody;ACADM_HUMAN antibody;Acyl coenzyme A dehydrogenase antibody;Acyl coenzyme A dehydrogenase C 4 to C 12 straight chain antibody;FLJ18227 antibody;FLJ93013 antibody;FLJ99884 antibody;MCAD antibody;MCADH antibody;Medium chain acyl CoA dehydrogenase antibody;Medium chain fatty acyl CoA dehydrogenase antibody;Medium chain specific acyl CoA dehydrogenase antibody;Medium chain specific acyl CoA dehydrogenase mitochondrial antibody;Medium-chain specific acyl-CoA dehydrogenase antibody;mitochondrial antibody

SEQUENCE SIMILARITIES

Belongs to the acyl-CoA dehydrogenase family.

POST-TRANSLATIONAL MODIFICATION

Acetylation at Lys-307 and Lys-311 in proximity of the cofactor-binding sites reduces catalytic activity (By similarity). These sites are deacetylated by SIRT3.

SUBCELLULAR LOCATION

Mitochondrion matrix.

FUNCTION

ACADM (acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain) is a gene that provides instructions for making an enzyme called acyl-coenzyme A dehydrogenase that is important for breaking down (degrading) a certain group of fats called medium-chain fatty acids. These fatty acids are found in foods such as milk and certain oils, and they are also stored in the body's fat tissue. Medium-chain fatty acids are also produced when larger fatty acids are degraded. The acyl-coenzyme A dehydrogenase for medium-chain fatty acids (ACADM) enzyme is essential for converting these particular fatty acids to energy, especially during periods without food (fasting). The ACADM enzyme functions in mitochondria, the energy-producing centers within cells. It is found in the mitochondria of several types of tissues, particularly the liver. The LCAD enzyme catalyzes most of fatty acid beta-oxidation by forming a C2-C3 trans-double bond in the fatty acid. MCAD works on long-chain fatty acids, typically between C4 and C12-acylCoA. Fatty acid oxidation has proven to spare glucose in fasting conditions, and is also required for amino acid metabolism, which is essential for the maintenance of adequate glucose production.