ABCG1 Recombinant Rabbit Monoclonal Antibody [SU03-26] (ET1608-20)

UNIPROT #

P45844

PROTEIN NAME

ABCG1

SYNONYMS

ABC transporter 8 antibody;ABC8 antibody;ABCG1 antibody;ABCG1_HUMAN antibody;ATP-binding cassette sub family G member 1 antibody;ATP-binding cassette sub-family G member 1 antibody;ATP-binding cassette transporter 8 antibody;ATP-binding cassette transporter member 1 of subfamily G antibody;ATP-binding cassette, sub family G WHITE member 1 antibody;homolog of Drosophila white antibody;MGC34313 antibody;White protein homolog antibody;White protein homolog ATP binding cassette transporter 8 antibody;WHITE1 antibody;WHT1 antibody

SEQUENCE SIMILARITIES

Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.

TISSUE SPECIFICITY

Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.

POST-TRANSLATIONAL MODIFICATION

Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.

SUBCELLULAR LOCATION

Endoplasmic reticulum membrane, Golgi apparatus membrane.

FUNCTION

ATP-binding cassette sub-family G member 1 is a protein that in humans is encoded by the ABCG1 gene. It is a homolog of the well-known Drosophila gene white. The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage, cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types.