Lane 1: THP-1 cell lysate
Lane 2: MCF-7 cell lysate
Recombinant Rabbit monoclonal primary
ABCG1 Recombinant Rabbit Monoclonal Antibody [SU03-26] (ET1608-20)
THP-1 cell lysate, MCF-7 cell lysate, human lung tissue, human skin tissue.
Store at +4C after thawing. Aliquot store at -20C or -80C. Avoid repeated freeze / thaw cycles.
1*TBS (pH7.4), 0.05% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Protein A affinity purified.
ABC transporter 8 antibody; ABC8 antibody; ABCG1 antibody; ABCG1_HUMAN antibody; ATP-binding cassette sub family G member 1 antibody; ATP-binding cassette sub-family G member 1 antibody; ATP-binding cassette transporter 8 antibody; ATP-binding cassette transporter member 1 of subfamily G antibody; ATP-binding cassette, sub family G WHITE member 1 antibody; homolog of Drosophila white antibody; MGC34313 antibody; White protein homolog antibody; White protein homolog ATP binding cassette transporter 8 antibody; WHITE1 antibody; WHT1 antibody
Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.
Expressed in several tissues. Expressed in macrophages; expression is increased in macrophages from patients with Tangier disease.
Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum.
Endoplasmic reticulum membrane, Golgi apparatus membrane.
ABCG1 (also designated ABC8 or human white gene), a member of the evolutionary conserved family of ATP-binding cassette (ABC) transporters, exhibits high homology with the Drosophila white gene. ABC transporters couple the energy of ATP hydrolysis to the translocation of various molecules across biological membranes. These proteins contain characteristic ATP-binding domains and transmembrane domains which form a channel-like structure for transport. ABCG1 functions to regulate cholesterol and phospholipid transport in macrophages. ABCG1 is highly expressed in several tissues, including brain, spleen, lung and placenta, and has been localized to the cell surface and intracellular compartments of cholesterol-laden macrophages.