ABCC4 Recombinant Rabbit Monoclonal Antibody - BSA and Azide free [PSH23-61] (HA751903)

UNIPROT #

O15439

PROTEIN NAME

ABCC4

SYNONYMS

ABCC 4 antibody;ABCC4 antibody;ATP binding cassette sub family C (CFTR/MRP) member 4 antibody;ATP binding cassette sub family C member 4 antibody;ATP-binding cassette sub-family C member 4 antibody;bA464I2.1 (ATP binding cassette;sub-family C (CFTR/MRP) member 4) antibody;bA464I2.1 antibody;Canalicular multispecific organic anion transporter antibody;Canalicular multispecific organic anion transporter ABC superfamily antibody;EST170205 antibody;MOAT B antibody;MOAT-B antibody;MOATB antibody;MRP 4 antibody;MRP/cMOAT related ABC transporter antibody;MRP/cMOAT-related ABC transporter antibody;MRP4_HUMAN antibody;Multi specific organic anion transporter B antibody;Multi-specific organic anion transporter B antibody;Multidrug resistance associated protein 4 antibody;Multidrug resistance-associated protein 4 antibody;OTTHUMP00000018560 antibody

SUBCELLULAR LOCATION

Basolateral cell membrane, Apical cell membrane.

FUNCTION

ATP-binding cassette sub-family C member 4 (ABCC4), also known as the multidrug resistance-associated protein 4 (MRP4) or multi-specific organic anion transporter B (MOAT-B), is a protein that in humans is encoded by the ABCC4 gene. ABCC4 acts as a regulator of intracellular cyclic nucleotide levels and as a mediator of cAMP-dependent signal transduction to the nucleus. MRP4/ABCC4 also transports prostaglandins, for example PGE2, out of the cell where they can bind receptors. MRP4/ABCC4 expression is dysregulated in several cancers and is also upregulated in peritoneal endometriosis.