ABAT / GABA-T Recombinant Rabbit Monoclonal Antibody [JE50-16] (ET7110-01)

UNIPROT #

P80404

PROTEIN NAME

ABAT/GABA-T

SYNONYMS

(S) 3 amino 2 methylpropionate transaminase antibody;(S)-3-amino-2-methylpropionate transaminase antibody;4 aminobutyrate aminotransferase antibody;4 aminobutyrate aminotransferase, mitochondrial antibody;4-aminobutyrate aminotransferase antibody;ABAT antibody;FLJ17813 antibody;FLJ30272 antibody;GABA aminotransferase antibody;GABA AT antibody;GABA T antibody;GABA transaminase antibody;GABA transferase antibody;GABA-AT antibody;GABA-T antibody;GABAT antibody;GABT_HUMAN antibody;Gamma amino N butyrate transaminase antibody;Gamma-amino-N-butyrate transaminase antibody;hCG1984265 antibody;L AIBAT antibody;L-AIBAT antibody;LAIBAT antibody;mitochondrial antibody;NPD009 antibody

SEQUENCE SIMILARITIES

Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.

TISSUE SPECIFICITY

Liver > pancreas > brain > kidney > heart > placenta.

SUBCELLULAR LOCATION

Mitochondrion.

FUNCTION

4-aminobutyrate aminotransferase (ABAT) is responsible for catabolism of gamma-aminobutyric acid (GABA), an important, mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. The active enzyme is a homodimer of 50-kD subunits complexed to pyridoxal-5-phosphate. The protein sequence is over 95% similar to the pig protein. GABA is estimated to be present in nearly one-third of human synapses. ABAT in liver and brain is controlled by 2 codominant alleles with a frequency in a Caucasian population of 0.56 and 0.44. The ABAT deficiency phenotype includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Multiple alternatively spliced transcript variants encoding the same protein isoform have been found for this gene.