STIP1 Recombinant Rabbit Monoclonal Antibody [JB95-38]

Function

Stress-induced-phosphoprotein 1 (STI1) functions as a co-chaperone for HSP70 and HSP90 during heat shock response. STI1 exists as either a monomer or a dimer, and this conformational flexibility facilitates its function in organizing HSP70/HSP90. HSP90 acts as an ATPase, and requires the recruitment of client proteins and proper conformation to function. STI1 acts as a "scaffold" for client protein recruitment to the relaxed, ADP-bound conformation of HSP90, thus suppressing ATP turnover during the loading phase and allowing proper function.

Background References

1. Woodford M R et al. The FNIP co-chaperones decelerate the Hsp90 chaperone cycle and enhance drug binding. Nat Commun 7:12037-12037 (2016).

2. Silverstein A M et al. Protein phosphatase 5 is a major component of glucocorticoid receptor.hsp90 complexes with properties of an FK506-binding immunophilin. J Biol Chem 272:16224-16230 (1997).

Subcellular Location

Cytoplasm, Nucleus.

UNIPROT

SwissProt: P31948 Human

SwissProt: Q60864 Mouse

SwissProt: O35814 Rat

Synonyms