MEKK2 Recombinant Rabbit Monoclonal Antibody [SC68-02]

Function

Mitogen-activated protein (MAP) kinase cascades are activated by various extracellular stimuli including growth factors. The MEK kinases (also designated MAP kinase kinase kinases, MKKKs, MAP3Ks or MEKKs) phosphorylate and thereby activate the MEKs (also called MAP kinase kinases or MKKs), including ERK, JNK and p38. These activated MEKs in turn phosphorylate and activate the MAP kinases. The MEK kinases include Raf-1, Raf-B, Mos, MEK kinase-1, MEK kinase-2, MEK kinase-3, MEK kinase-4, ASK 1 (MEK kinase-5) and MAP3K6 (MEK kinase-6). MEK kinase-1 has been shown to phosphorylate MEK-1 via a Raf-independent pathway. Evidence suggests that MEK-3 is preferentially activated by MEK kinase-3 and that MEK-4 is activated by both MEK kinase-2 and MEK kinase-3. MEK kinase-4 has been shown to specifically activate the JNK pathway. ASK 1 activates both MEK-4 and MEK-3/MEK-6 pathways.

Background References

1. Mazur PK et al. SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Nature 510:283-7 (2014).

2. Brown RD et al. MAP kinase kinase kinase-2 (MEKK2) regulates hypertrophic remodeling of the right ventricle in hypoxia-induced pulmonary hypertension. Am J Physiol Heart Circ Physiol 304:H269-81 (2013).

Sequence Similarity

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.

Post-translational Modification

Autophosphorylated.; Ubiquitination by XIAP/BIRC4 does not lead to proteasomal degradation.

Subcellular Location

Cytoplasm, Nucleus.

UNIPROT

SwissProt: Q9Y2U5 Human

SwissProt: Q61083 Mouse

Unigene: 213212 Rat

Synonyms

M3K2_HUMAN antibody

Map3k2 antibody

MAPK/ERK kinase kinase 2 antibody

MEK kinase 2 antibody

MEKK 2 antibody

MEKK2b antibody

Mitogen activated protein kinase kinase kinase 2 antibody

Mitogen-activated protein kinase kinase kinase 2 antibody