CD19 Rabbit Polyclonal Antibody

Function

B-lymphocyte antigen CD19 also known as CD19 (Cluster of Differentiation 19), is a 95 kDa type-I transmembrane glycoprotein which is restricted to B cell antigen. On the B cell surface, CD19 associates with CD21, CD81 and Leu-13 to exert its function. CD19 is also found on the follicular dendritic cells and the early cells of myelomonocytic lineage but not on normal T cells, NK cells, monocytes, granulocytes, erythrocytes and platelets.

Background References

1. "An antibody-deficiency syndrome due to mutations in the CD19 gene."van Zelm M.C., Reisli I., van der Burg M., Castano D., van Noesel C.J.M., van Tol M.J.D., Woellner C., Grimbacher B., Patino P.J., van Dongen J.J.M., Franco J.L.N. Engl. J. Med. 354:1901-1912(2006)

2. "Systematic analysis of the role of CD19 cytoplasmic tyrosines in enhancement of activation in Daudi human B cells: clustering of phospholipase C and Vav and of Grb2 and Sos with different CD19 tyrosines."Brooks S.R., Li X., Volanakis E.J., Carter R.H.J. Immunol. 164:3123-3131(2000)

Tissue Specificity

Detected on marginal zone and germinal center B cells in lymph nodes. Detected on blood B cells (at protein level).

Post-translational Modification

Phosphorylated on tyrosine following B-cell activation. Phosphorylated on tyrosine residues by LYN. Tyrosine residues are phosphorylated sequentially after activation of the B cell receptor. Phosphorylation of Tyr-531 is extremely rapid, followed by phosphorylation at Tyr-409. In contrast, phosphorylation of Tyr-500 appears more slowly and is more transient, returning rapidly to basal levels (By similarity).

Subcellular Location

Cell membrane

UNIPROT

SwissProt: P15391 Human

SwissProt: P25918 Mouse

Synonyms