FOXD3 Rabbit Polyclonal Antibody

Function

Forkhead box protein D3 (FOXD3) acts as a transcriptional repressor and binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3'. It promotes development of neural crest cells from neural tube progenitors and restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. FOXD3 is expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord. A variety of growth factors induce FoxD3 expression, including FGF8 and SNAIL, maintaining the effected cells in an undifferentiated state.

Background References

1. "Requirement for Foxd3 in maintaining pluripotent cells of the early mouse embryo."Hanna L.A., Foreman R.K., Tarasenko I.A., Kessler D.S., Labosky P.A.Genes Dev. 16:2650-2661(2002)

2. "Lineage-specific biology revealed by a finished genome assembly of the mouse."Church D.M., et al. PLoS Biol. 7:E1000112-E1000112(2009)

Tissue Specificity

Expressed in premigratory and migrating neural crest cells in the early embryo and in motorneuron and interneuron progenitors in the developing spinal cord.

Subcellular Location

Nucleus

UNIPROT

SwissProt: Q9UJU5 Human

SwissProt: Q61060 Mouse

Synonyms

AIS1 antibody

forkhead box D3 antibody

Forkhead box protein D3 antibody

foxd3 antibody

FOXD3_HUMAN antibody

Genesis antibody

HFH2 antibody

HNF3/FH transcription factor genesis antibody

VAMAS2 antibody