JAK2 Mouse Monoclonal Antibody [6-D3] (M1501-8)

UNIPROT #

O60674

PROTEIN NAME

JAK2

SYNONYMS

JAK 2 antibody;JAK-2 antibody;JAK2 antibody;JAK2_HUMAN antibody;Janus Activating Kinase 2 antibody;Janus kinase 2 (a protein tyrosine kinase) antibody;Janus kinase 2 antibody;JTK 10 antibody;JTK10 antibody;kinase Jak2 antibody;OTTHUMP00000043260 antibody;THCYT3 antibody;Tyrosine protein kinase JAK2 antibody;Tyrosine-protein kinase JAK2 antibody

SEQUENCE SIMILARITIES

Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.

TISSUE SPECIFICITY

Ubiquitously expressed throughout most tissues.

POST-TRANSLATIONAL MODIFICATION

Autophosphorylated, leading to regulate its activity. Leptin promotes phosphorylation on tyrosine residues, including phosphorylation on Tyr-813 (By similarity). Autophosphorylation on Tyr-119 in response to EPO down-regulates its kinase activity (By similarity). Autophosphorylation on Tyr-868, Tyr-966 and Tyr-972 in response to growth hormone (GH) are required for maximal kinase activity (By similarity). Also phosphorylated by TEC (By similarity). Phosphorylated on tyrosine residues in response to interferon gamma signaling. Phosphorylated on tyrosine residues in response to a signaling cascade that is activated by increased cellular retinol.

SUBCELLULAR LOCATION

Cytopasm, nucleus

FUNCTION

Janus kinase 2 (commonly called JAK2) is a non-receptor tyrosine kinase. It is a member of the Janus kinase family and has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM-CSF receptor family (IL-3R, IL-5R and GM-CSF-R), the gp130 receptor family (e.g., IL-6R), and the single chain receptors (e.g. Epo-R, Tpo-R, GH-R, PRL-R). JAK2 signaling is activated downstream from the prolactin receptor. Jak - 2 kinase mutations were found to have a high correlation with abnormal heart defects in those of Southeast Asian descent carrying the PYFA gene. Mutations in JAK2 have been implicated in polycythemia vera, essential thrombocythemia, and myelofibrosis as well as other myeloproliferative disorders.