ATRX Mouse Monoclonal Antibody [2-E7] (M1311-2)

UNIPROT #

Q61687

PROTEIN NAME

ATRX

SYNONYMS

Alpha thalassemia/mental retardation syndrome X linked homolog antibody;ATP dependent helicase ATRX antibody;ATP-dependent helicase ATRX antibody;ATR2 antibody;Atrx antibody;ATRX_HUMAN antibody;DNA dependent ATPase and helicase antibody;Helicase 2, X linked antibody;MGC2094 antibody;MRXHF1 antibody;RAD54 antibody;RAD54L antibody;SFM1 antibody;SHS antibody;Transcriptional regulator ATRX antibody;X linked helicase II antibody;X linked nuclear protein antibody;X-linked helicase II antibody;X-linked nuclear protein antibody;XH2 antibody;XNP antibody;Znf HX antibody;Znf-HX antibody

SEQUENCE SIMILARITIES

Belongs to the SNF2/RAD54 helicase family.

POST-TRANSLATIONAL MODIFICATION

Citrullinated by PADI4.

SUBCELLULAR LOCATION

Nucleus

FUNCTION

Transcriptional regulator ATRX contains an ATPase / helicase domain, and thus it belongs to the SWI/SNF family of chromatin remodeling proteins. This protein is found to undergo cell cycle-dependent phosphorylation, which regulates its nuclear matrix and chromatin association, and suggests its involvement in the gene regulation at interphase and chromosomal segregation in mitosis. Mutations of the ATRX gene are associated with an X-linked mental retardation (XLMR) syndrome most often accompanied by alpha-thalassemia (ATRX) syndrome. These mutations have been shown to cause diverse changes in the pattern of DNA methylation, which may provide a link between chromatin remodeling, DNA methylation, and gene expression in developmental processes.