LRP-1 Mouse Monoclonal Antibody [A4-F5]
Catalog# M1211-4
LRP-1 Mouse Monoclonal Antibody [A4-F5]
-
WB
-
IHC-P
-
Mouse
-
unconjugated
Overview
Product Name
LRP-1 Mouse Monoclonal Antibody [A4-F5]
Antibody Type
Mouse Monoclonal Antibody
Immunogen
Recombinant protein within Mouse LRP-1 aa 1-500 / 4,545.
Species Reactivity
Mouse
Validated Applications
WB, IHC-P
Target Molecular Weight
Predicted band size: 505 kDa
Positive Control
Recombinant protein, mouse liver tissue.
Conjugation
unconjugated
Clone Number
A4-F5
RRID
Product Features
Form
Liquid
Concentration
2 mg/mL.(The concentration of this product may be batch-dependent)
Storage Instructions
Shipped at 4℃. Store at +4℃ short term (1-2 weeks). Store at -20℃ long term.
Storage Buffer
1*PBS (pH7.4), 0.2% BSA, 40% Glycerol. Preservative: 0.05% Sodium Azide.
Isotype
IgG2a
Purification Method
Protein A affinity purified.
Application Dilution
-
WB
-
1:1,000
-
IHC-P
-
1:50
Target
Function
The LDL receptor-related protein (LRP1) is a large endocytic receptor that is widely expressed in several tissues. LRP1 is a member of the LDL receptor family that plays diverse roles in various biological processes including lipoprotein metabolism, degradation of proteases, activation of lysosomal enzymes, and cellular entry of bacterial toxins and viruses.
Background References
1. "Functional expression of murine LRP1 requires correction of Lrp1 cDNA sequences."Smeijers L., Willems S., Lauwers A., Thiry E., van Leuven F., Roebroek A.J.M.Biochim. Biophys. Acta 1577:155-158(2002)
2. “Functional expression of the alpha 2-macroglobulin receptor CD91 in salivary gland epithelial cells.” Bourazopoulou,E; Moutsopoulos,HM;Tzioufas,AG。Journal of Autoimmunity . 2009vol.33(no.2)
Sequence Similarity
Belongs to the LDLR family.
Post-translational Modification
Phosphorylated on serine and threonine residues.; Phosphorylated on tyrosine residues upon stimulation with PDGF. Tyrosine phosphorylation promotes interaction with SHC1 (By similarity).; Cleaved into a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515) that remains non-covalently associated. Gamma-secretase-dependent cleavage of LRP-85 releases the intracellular domain from the membrane (By similarity).
Subcellular Location
cell membrane.
UNIPROT
Synonyms
A2MR antibody
Alpha 2 macroglobulin receptor antibody
alpha 2MR antibody
Alpha-2-macroglobulin receptor antibody
APOER antibody
Apolipoprotein E receptor antibody
APR antibody
CD 91 antibody
CD91 antibody
CD91 antigen antibody
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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