Caspase-7 Recombinant Rabbit Monoclonal Antibody [PSH13-69] (HA723558)

UNIPROT #

P55210

PROTEIN NAME

Caspase-7

SYNONYMS

Apoptotic protease Mch-3 antibody;Apoptotic protease MCH3 antibody;CASP-7 antibody;CASP7 antibody;CASP7_HUMAN antibody;Caspase 7 antibody;Caspase 7 apoptosis related cysteine peptidase antibody;Caspase-7 subunit p11 antibody;Caspase7 antibody;CMH 1 antibody;CMH-1 antibody;CMH1 antibody;ICE LAP3 antibody;ICE-LAP3 antibody;ICE-like apoptotic protease 3 antibody;LICE2 antibody;MCH3 antibody

SUBCELLULAR LOCATION

Cytoplasm, cytosol, Nucleus, Secreted, extracellular space.

FUNCTION

Caspase-7, apoptosis-related cysteine peptidase, also known as CASP7, is a human protein encoded by the CASP7 gene. CASP7 orthologs have been identified in nearly all mammals for which complete genome data are available. Unique orthologs are also present in birds, lizards, lissamphibians, and teleosts. Caspase-7 is a member of the caspase (cysteine aspartate protease) family of proteins, and has been shown to be an executioner protein of apoptosis. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes that undergo proteolytic processing by upstream caspases (caspase-8, -9) at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme in the form of a heterotetramer. The precursor of this caspase is cleaved by caspase 3, caspase 10, and caspase 9. It is activated upon cell death stimuli and induces apoptosis. Alternative splicing results in four transcript variants, encoding three distinct isoforms.