DMT1 Recombinant Rabbit Monoclonal Antibody [PSH09-20] (HA723078)

UNIPROT #

P49281

PROTEIN NAME

DMT1

SYNONYMS

DCT 1 antibody;dct-1 antibody;DCT1 antibody;Divalent cation transporter 1 antibody;Divalent metal transporter 1 antibody;DMT 1 antibody;DMT-1 antibody;DMT1 antibody;FLJ37416 antibody;Natural resistance associated macrophage protein 2 antibody;Natural resistance-associated macrophage protein 2 antibody;NRAM2_HUMAN antibody;NRAMP 2 antibody;NRAMP2 antibody;OK/SW-cl.20 antibody;Slc11a2 antibody;Solute carrier family 11 (proton coupled divalent metal ion transporters) member 2 antibody;Solute carrier family 11 member 2 antibody

SUBCELLULAR LOCATION

Mitochondrion outer membrane, Golgi apparatus, trans-Golgi network membrane, Recycling endosome membrane.

FUNCTION

Natural resistance-associated macrophage protein 2 (NRAMP 2), also known as divalent metal transporter 1 (DMT1) and divalent cation transporter 1 (DCT1), is a protein that in humans is encoded by the SLC11A2 (solute carrier family 11, member 2) gene. DMT1 represents a large family of orthologous metal ion transporter proteins that are highly conserved from bacteria to humans. As its name suggests, DMT1 binds a variety of divalent metals including cadmium (Cd2+), copper (Cu2+), and zinc (Zn2+,); however, it is best known for its role in transporting ferrous iron (Fe2+). DMT1 expression is regulated by body iron stores to maintain iron homeostasis. DMT1 is also important in the absorption and transport of manganese (Mn2+). In the digestive tract, it is located on the apical membrane of enterocytes, where it carries out H+-coupled transport of divalent metal cations from the intestinal lumen into the cell. Iron is not only essential for the human body, it is required for all organisms in order for them to be able to grow. Iron also participates in many metabolic pathways. Iron deficiency can lead to iron-deficiency anemia thus iron regulation is very crucial in the human body.