Mucolipin-1 Recombinant Rabbit Monoclonal Antibody [PSH09-01] (HA723054)

UNIPROT #

Q9GZU1

PROTEIN NAME

Mucolipin-1

SYNONYMS

MCLN1_HUMAN antibody;Mcoln 1 antibody;Mcoln1 antibody;MG 2 antibody;MG-2 antibody;MG2 antibody;ML 4 antibody;ML4 antibody;MLIV antibody;MST080 antibody;MSTP080 antibody;Mucolipidin antibody;Mucolipin 1 antibody;Mucolipin-1 antibody;Mucolipin1 antibody;TRP ML1 antibody;TRPML1 antibody

SUBCELLULAR LOCATION

Late endosome membrane, Lysosome membrane, Cytoplasmic vesicle membrane, Cell projection, phagocytic cup, Cytoplasmic vesicle, phagosome membrane, Cell membrane.

FUNCTION

Mucolipin-1 (ML1) also known as TRPML1 (transient receptor potential cation channel, mucolipin subfamily, member 1) is a protein that in humans is encoded by the MCOLN1 gene. It is a member of the small family of the TRPML channels, a subgroup of the large protein family of TRP ion channels. TRPML1 is a 65 kDa protein associated with mucolipidosis type IV. Its predicted structure includes six transmembrane domains, a transient receptor potential (TRP) cation-channel domain, and an internal channel pore. TRPML1 is believed to channel iron ions across the endosome/lysosome membrane into the cell and so its malfunction causes cellular iron deficiency. It is important in lysosome function and plays a part in processes such as vesicular trafficking, exocytosis and autophagy.