PD-L1 Recombinant Rabbit Monoclonal Antibody [PSH08-56] (HA723002)

UNIPROT #

A8WEV0

PROTEIN NAME

PD-L1

SYNONYMS

B7 H antibody;B7 H1 antibody;B7 homolog 1 antibody;B7-H1 antibody;B7H antibody;B7H1 antibody;CD 274 antibody;CD-274 antibody;CD274 antibody;CD274 antigen antibody;CD274 molecule antibody;MGC142294 antibody;MGC142296 antibody;OTTHUMP00000021029 antibody;PD L1 antibody;PD-L1 antibody;PD1L1_HUMAN antibody;PDCD1 ligand 1 antibody;PDCD1L1 antibody;PDCD1LG1 antibody;PDL 1 antibody;PDL1 antibody;Programmed cell death 1 ligand 1 antibody;Programmed death ligand 1 antibody;RGD1566211 antibody

SUBCELLULAR LOCATION

Membrane.

FUNCTION

Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. Normally the adaptive immune system reacts to antigens that are associated with immune system activation by exogenous or endogenous danger signals. In turn, clonal expansion of antigen-specific CD8+ T cells and/or CD4+ helper cells is propagated. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) – further mediated by a lower regulation of the gene Bcl-2. PD-L1 is expressed on both hematopoietic and nonhematopoietic cells in tissues. However, the exact roles of PD-L1 on hematopoietic versus nonhematopoietic cells in modulating immune responses are unclear.