HMGCS1 Recombinant Rabbit Monoclonal Antibody [PSH08-52] (HA722998)

UNIPROT #

Q01581

PROTEIN NAME

HMGCS1

SYNONYMS

3 hydroxy 3 methylglutaryl Coenzyme A synthase 1 (soluble) antibody;3-hydroxy-3-methylglutaryl coenzyme A synthase antibody;cytoplasmic antibody;EC 2.3.3.10 antibody;HMCS1_HUMAN antibody;HMG CoA synthase antibody;HMG-CoA synthase antibody;HMGCS antibody;HMGCS1 antibody;Hydroxymethylglutaryl CoA synthase, cytoplasmic antibody;Hydroxymethylglutaryl-CoA synthase antibody;MGC90332 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

In biochemistry, hydroxymethylglutaryl-CoA synthase or HMG-CoA synthase EC 2.3.3.10 is an enzyme which catalyzes the reaction in which acetyl-CoA condenses with acetoacetyl-CoA to form 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA). This reaction comprises the second step in the mevalonate-dependent isoprenoid biosynthesis pathway. HMG-CoA is an intermediate in both cholesterol synthesis and ketogenesis. This reaction is overactivated in patients with diabetes mellitus type 1 if left untreated, due to prolonged insulin deficiency and the exhaustion of substrates for gluconeogenesis and the TCA cycle, notably oxaloacetate. This results in shunting of excess acetyl-CoA into the ketone synthesis pathway via HMG-CoA, leading to the development of diabetic ketoacidosis. In humans, the protein is encoded by the HMGCS1 gene on chromosome 5.