Presenilin 1 / PS-1 Recombinant Rabbit Monoclonal Antibody [PSH08-49] (HA722995)

UNIPROT #

P49768

PROTEIN NAME

Presenilin 1

SYNONYMS

AD3 antibody;Ad3h antibody;FAD antibody;Homo Sapiens Clone CC44 Senilin 1 antibody;Presenilin-1 CTF12 antibody;Protein S182 antibody;PS 1 antibody;PS-1 antibody;PS1-CTF12 antibody;PSEN1 antibody;PSN1_HUMAN antibody;PSNL1 antibody;S182 antibody

SUBCELLULAR LOCATION

Endoplasmic reticulum, Endoplasmic reticulum membrane, Golgi apparatus membrane, Cytoplasmic granule, Cell membrane, Cell projection, growth cone, Early endosome, Early endosome membrane, neuron projection, axon, Synapse.

FUNCTION

Presenilin-1 (PS-1) is a presenilin protein that in humans is encoded by the PSEN1 gene. Presenilin-1 is one of the four core proteins in the gamma secretase complex, which is considered to play an important role in generation of amyloid beta (Aβ) from amyloid-beta precursor protein (APP). Accumulation of amyloid beta is associated with the onset of Alzheimer's disease. Presenilins are postulated to regulate APP processing through their effects on gamma secretase, an enzyme that cleaves APP. Also, it is thought that the presenilins are involved in the cleavage of the Notch receptor, such that they either directly regulate gamma secretase activity or themselves are protease enzymes. Multiple alternatively spliced transcript variants have been identified for this gene, the full-length natures of only some have been determined.