COL1A2 Recombinant Rabbit Monoclonal Antibody [PSH07-21] (HA722809)

UNIPROT #

P08123

PROTEIN NAME

COL1A2

SYNONYMS

Alpha 2 collagen type I antibody;Alpha 2 type I collagen antibody;Alpha 2 type I procollagen antibody;Alpha 2(I) collagen antibody;Alpha 2(I) procollagen antibody;Alpha-2 type I collagen antibody;CO1A2_HUMAN antibody;COL1A2 antibody;Collagen alpha 2(I) chain antibody;Collagen alpha-2(I) chain antibody;Collagen I alpha 2 polypeptide antibody;Collagen of skin tendon and bone alpha 2 chain antibody;Collagen type I alpha 2 antibody;OI4 antibody;Osteogenesis imperfecta type IV antibody;Type I procollagen antibody

SUBCELLULAR LOCATION

Secreted, extracellular space, extracellular matrix.

FUNCTION

Collagen alpha-2(I) chain is a protein that in humans is encoded by the COL1A2 gene. This gene encodes one of the chains for type I collagen, the fibrillar collagen found in most connective tissues. Mutations in this gene are associated with osteogenesis imperfecta, Cardiac-valvular, and Arthrochlasia type Ehlers-Danlos syndrome, idiopathic osteoporosis, and atypical Marfan syndrome. Symptoms associated with mutations in this gene, however, tend to be less severe than mutations in the gene for alpha-1 type I collagen, since alpha-2 is less abundant. Multiple messages for this gene result from multiple polyadenylation signals, a feature shared by most of the other collagen genes.