Phospho-Cofilin (S3) Recombinant Rabbit Monoclonal Antibody [PSH07-18]

Function

Cofilin 1 (non-muscle; n-cofilin), also known as CFL1, is a human gene, part of the ADF/cofilin family. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus. One group reports that reelin signaling leads to serine3-phosphorylation of cofilin-1, and this interaction may play a role in the reelin-related regulation of neuronal migration.

Background References

1. Hoffmann L et al. Cofilin1 oxidation links oxidative distress to mitochondrial demise and neuronal cell death. Cell Death Dis. 2021 Oct

2. Salz A et al. Cofilin1-driven actin dynamics controls migration of thymocytes and is essential for positive selection in the thymus. J Cell Sci. 2020 Mar

Subcellular Location

Nucleus matrix, Cytoplasm, cytoskeleton, Cell projection, ruffle membrane, lamellipodium membrane, lamellipodium, growth cone, axon.

UNIPROT

SwissProt: P23528 Human

SwissProt: P45592 Rat

Synonyms