ATF-4 Recombinant Rabbit Monoclonal Antibody [PSH07-08] (HA722796)

UNIPROT #

P18848

PROTEIN NAME

ATF-4

SYNONYMS

Activating transcription factor 4 antibody;ATF 4 antibody;ATF4 antibody;ATF4 protein antibody;ATF4_HUMAN antibody;cAMP-dependent transcription factor ATF-4 antibody;cAMP-responsive element-binding protein 2 antibody;CREB 2 antibody;CREB-2 antibody;CREB2 antibody;Cyclic AMP dependent transcription factor ATF 4 antibody;Cyclic AMP response element binding protein 2 antibody;Cyclic AMP-dependent transcription factor ATF-4 antibody;Cyclic AMP-responsive element-binding protein 2 antibody;DNA binding protein TAXREB67 antibody;DNA-binding protein TAXREB67 antibody;Tax Responsive Enhancer Element B67 antibody;Tax-responsive enhancer element-binding protein 67 antibody;TaxREB67 antibody;TXREB antibody

SUBCELLULAR LOCATION

Nucleus, Nucleus speckle, Cytoplasm, Cell membrane, cytoskeleton, microtubule organizing center, centrosome.

FUNCTION

Activating transcription factor 4 (tax-responsive enhancer element B67), also known as ATF4, is a protein that in humans is encoded by the ATF4 gene. ATF4 transcription factor is also known to play role in osteoblast differentiation along with RUNX2 and osterix. Terminal osteoblast differentiation, represented by matrix mineralization, is significantly inhibited by the inactivation of JNK. JNK inactivation downregulates expression of ATF-4 and, subsequently, matrix mineralization. IMPACT protein regulates ATF4 in C. elegans to promote lifespan. ATF4 is also involved in the cannabinoid Δ9-tetrahydrocannabinol–induced apoptosis in cancer cells, by the proapoptotic role of the stress protein p8 via its upregulation of the endoplasmic reticulum stress-related genes ATF4, CHOP, and TRB3.