FOLR1 Recombinant Rabbit Monoclonal Antibody [PSH06-93] (HA722768)

UNIPROT #

P15328

PROTEIN NAME

FOLR1

SYNONYMS

adult antibody;Adult folate binding protein antibody;Adult folate-binding protein antibody;FBP antibody;Folate Binding Protein antibody;Folate Receptor 1 Adult antibody;Folate receptor 1 antibody;Folate Receptor 1 Precursor antibody;Folate receptor adult antibody;Folate receptor alpha antibody;Folate receptor antibody;FOLR antibody;FOLR1 antibody;FOLR1_HUMAN antibody;FR alpha antibody;FR-alpha antibody;FRalpha antibody;KB cells FBP antibody;MOV18 antibody;Ovarian cancer associated antigen antibody;Ovarian tumor associated antigen antibody;Ovarian tumor associated antigen MOv18 antibody;Ovarian tumor-associated antigen MOv18 antibody

SUBCELLULAR LOCATION

Cell membrane, Apical cell membrane, Basolateral cell membrane, Secreted, Cytoplasmic vesicle, clathrin-coated vesicle, Endosome.

FUNCTION

Folate receptor 1 (Folate receptor alpha, FOLR1) is a protein that in humans is encoded by the FOLR1 gene. The protein encoded by this gene is a member of the folate receptor (FOLR) family. Members of this family have a high affinity for folic acid and for several reduced folic acid derivatives, and mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This receptor is responsible for binding to folic acid and its derivatives, which becomes crucial during fetal development. By adding folate supplementation during pregnancy, neural tube defects in the fetus are prevented. Folate derivatives are necessary for important metabolic processes such as DNA, protein and lipid methylation. More importantly, folate plays a major role in DNA replication and cell division, which are common characteristics of rapid growth. Even though it is unclear how folate affects neural tube formation, scientists are certain that without appropriate folate levels, neural tube defects can develop through human and mice studies. Neural tube defects refer to the improper development of the neural tube by not being sealed correctly. This results in exencephaly or spina bifida, both nervous system abnormalities. This gene is composed of 7 exons; exons 1 through 4 encode the 5' UTR and exons 4 through 7 encode the open reading frame. Due to the presence of 2 promoters, multiple transcription start sites, and alternative splicing of exons, several transcript variants are derived from this gene. These variants differ in the lengths of 5' and 3' UTR, but they encode an identical amino acid sequence.