CSPP1 Recombinant Rabbit Monoclonal Antibody [PSH06-32]

Function

This gene encodes a centrosome and spindle pole associated protein. The encoded protein plays a role in cell-cycle progression and spindle organization, regulates cytokinesis, interacts with Nephrocystin 8 and is required for cilia formation. Mutations in this gene result in primary cilia abnormalities and classical Joubert syndrome. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

Background References

1. Wang W et al. Identifies microtubule-binding protein CSPP1 as a novel cancer biomarker associated with ferroptosis and tumor microenvironment. Comput Struct Biotechnol J. 2022 Jun

2. Yang G et al. Circ-CSPP1 knockdown suppresses hepatocellular carcinoma progression through miR-493-5p releasing-mediated HMGB1 downregulation. Cell Signal. 2021 Oct

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, spindle, spindle pole.

UNIPROT

SwissProt: Q1MSJ5 Human

SwissProt: B2RX88 Mouse

Entrez Gene: 362472 Rat

Synonyms

Centrosome and spindle pole-associated protein 1

CSPP1

CSPP