Phospho-AMPK alpha 2 (S491) Recombinant Rabbit Monoclonal Antibody [JE59-49] (HA722567)

UNIPROT #

P54646

PROTEIN NAME

Phospho-AMPK alpha 2 (S491)

SYNONYMS

5'-AMP-activated protein kinase catalytic subunit alpha-2 antibody;AAPK2_HUMAN antibody;ACACA kinase antibody;Acetyl CoA carboxylase kinase antibody;Acetyl-CoA carboxylase kinase antibody;AMPK alpha 2 chain antibody;AMPK subunit alpha-2 antibody;AMPK2 antibody;AMPKa2 antibody;AMPKalpha2 antibody;HMGCR kinase antibody;Hydroxymethylglutaryl CoA reductase kinase antibody;Hydroxymethylglutaryl-CoA reductase kinase antibody;PRKAA antibody;PRKAA2 antibody;Protein kinase AMP activated alpha 2 catalytic subunit antibody;Protein kinase AMP activated catalytic subunit alpha 2 antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

5'-AMP-activated protein kinase catalytic subunit alpha-2 is an enzyme that in humans is encoded by the PRKAA2 gene. The protein encoded by this gene is a catalytic subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. Studies of the mouse counterpart suggest that this catalytic subunit may control whole-body insulin sensitivity and is necessary for maintaining myocardial energy homeostasis during ischemia.