Phospho-Smad1/5/9 (S463/S465/S467) Recombinant Rabbit Monoclonal Antibody [JE59-46] (HA722566)

UNIPROT #

Q15797

PROTEIN NAME

Phospho-Smad1/5/9 (S463/S465/S467)

SYNONYMS

BSP-1 antibody;BSP1 antibody;HsMAD1 antibody;JV4-1 antibody;JV41 antibody;MAD homolog 1 antibody;MAD mothers against decapentaplegic homolog 1 antibody;Mad related protein 1 antibody;Mad-related protein 1 antibody;MADH1 antibody;MADR1 antibody;Mothers against decapentaplegic homolog 1 antibody;Mothers against DPP homolog 1 antibody;SMA- AND MAD-RELATED PROTEIN 1 antibody;SMAD 1 antibody;SMAD family member 1 antibody;SMAD mothers against DPP homolog 1 antibody;Smad1 antibody;SMAD1_HUMAN antibody;TGF beta signaling protein 1 antibody;Transforming growth factor-beta-signaling protein 1 antibody;DKFZp781C1895 antibody;DKFZp781O1323 antibody;Dwfc antibody;hSmad5 antibody;JV5 1 antibody;JV5-1 antibody;MAD homolog 5 antibody;MAD, mothers against decapentaplegic homolog 5 antibody;MADH 5 antibody;MADH5 antibody;Mothers against decapentaplegic homolog 5 antibody;mothers against decapentaplegic, drosophila, homolog of, 5 antibody;Mothers against DPP homolog 5 antibody;MusMLP antibody;SMA and MAD related protein 5 antibody;SMAD 5 antibody;SMAD family member 5 antibody;SMAD, mothers against DPP homolog 5 antibody;Smad5 antibody;SMAD5_HUMAN antibody;MAD homolog 9 antibody;Madh6 antibody;Mothers against decapentaplegic antibody;Mothers against decapentaplegic homolog 9 antibody;Mothers against DPP homolog 9 antibody;SMAD 9 antibody;SMAD family member 9 antibody;SMAD, mothers against DPP homolog 9 (Drosophila) antibody;SMAD8A antibody;SMAD8B antibody;Smad9 antibody;SMAD9_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus, Mitochondrion.

FUNCTION

Smads (or SMADs) comprise a family of structurally similar proteins that are the main signal transducers for receptors of the transforming growth factor beta (TGF-B) superfamily, which are critically important for regulating cell development and growth. There are three distinct sub-types of Smads: receptor-regulated Smads (R-Smads), common partner Smads (Co-Smads), and inhibitory Smads (I-Smads). The eight members of the Smad family are divided among these three groups. Trimers of two receptor-regulated SMADs and one co-SMAD act as transcription factors that regulate the expression of certain genes. The R-Smads consist of Smad1, Smad2, Smad3, Smad5 and Smad8/9, and are involved in direct signaling from the TGF-B receptor. R/Co-Smads are primarily located in the cytoplasm, but accumulate in the nucleus following TGF-β signaling, where they can bind to DNA and regulate transcription. However, I-Smads are predominantly found in the nucleus, where they can act as direct transcriptional regulators.