CD97 Recombinant Rabbit Monoclonal Antibody [JE57-33] (HA722563)

UNIPROT #

P48960

PROTEIN NAME

CD97

SYNONYMS

ADGRE5 antibody;Adhesion G protein-coupled receptor E5 antibody;CD 97 antibody;CD_antigen=CD97 antibody;CD97 antibody;CD97 antigen antibody;CD97 antigen subunit beta antibody;CD97 molecule antibody;CD97_HUMAN antibody;Leukocyte antigen CD97 antibody;Seven span transmembrane protein antibody;Seven transmembrane helix receptor antibody;Seven transmembrane heterodimeric receptor associated with inflammation antibody;TM7LN 1 antibody;TM7LN1 antibody

SUBCELLULAR LOCATION

Cell membrane.

FUNCTION

Cluster of differentiation 97 is a protein also known as BL-Ac[F2] encoded by the ADGRE5 gene. CD97 is a member of the adhesion G protein-coupled receptor (GPCR) family. Adhesion GPCRs are characterized by an extended extracellular region often possessing N-terminal protein modules that is linked to a TM7 region via a domain known as the GPCR-Autoproteolysis INducing (GAIN) domain. CD97 is widely expressed on, among others, hematopoietic stem and progenitor cells, immune cells, epithelial cells, muscle cells as well as their malignant counterparts. In the case of CD97 the N-terminal domains consist of alternatively spliced epidermal growth factor (EGF)-like domains. Alternative splicing has been observed for this gene and three variants have been found. The N-terminal fragment of CD97 contains 3-5 EGF-like domains in human and 3-4 EGF-like domains in mice.