MCT1 Recombinant Rabbit Monoclonal Antibody [JE41-72] (HA722556)

UNIPROT #

P53985

PROTEIN NAME

MCT1

SYNONYMS

FLJ36745 antibody;HHF7 antibody;MCT 1 antibody;MCT antibody;MGC44475 antibody;Monocarboxylate transporter 1 antibody;Monocarboxylate transporter antibody;Monocarboxylate transporter isoform 1 antibody;Monocarboxylic acid transporter 1 antibody;MOT1_HUMAN antibody;Slc16a1 antibody;SLC16A1 protein antibody;Solute carrier family 16 (monocarboxylic acid transporters) member 1 antibody;Solute carrier family 16 member 1 (monocarboxylic acid transporter 1) antibody;Solute carrier family 16 member 1 antibody

SUBCELLULAR LOCATION

Cell membrane, Basolateral cell membrane, Apical cell membrane.

FUNCTION

Monocarboxylate transporter 1 is a ubiquitous protein that in humans is encoded by the SLC16A1 gene (also known as MCT1). It is a proton coupled monocarboxylate transporter. Detailed kinetic analysis of monocarboxylate transport in erythrocytes revealed that MCT1 operates through an ordered mechanism. MCT1 has a substrate binding site open to the extracellular matrix which binds a proton first followed by the lactate anion. The protein then undergoes a conformational change to a new ‘closed’’ conformation that exposes both the proton and lactate to the opposite surface of the membrane where they are released, lactate first and then the proton. For net transport of lactic acid, the rate-limiting step is the return of MCT1 without bound substrate to the open conformation. For this reason, exchange of one monocarboxylate inside the cell with another outside is considerably faster than net transport of a monocarboxylate across the membrane. MCT1 can be upregulated by PPAR-α, Nrf2, and AMPK.