CLP1 Recombinant Rabbit Monoclonal Antibody [JE61-01] (HA722462)

UNIPROT #

Q92989

PROTEIN NAME

CLP1

SYNONYMS

ATP/GTP binding protein antibody;Cleavage and polyadenylation factor I subunit 1 antibody;CLP 1 antibody;clp1 antibody;CLP1 cleavage and polyadenylation factor I subunit homolog antibody;CLP1, cleavage and polyadenylation factor I subunit, homolog (S. cerevisiae) antibody;CLP1, yeast, homolog of antibody;CLP1_HUMAN antibody;hClp1 antibody;Homolog of yeast CFIA subunit Clp1p antibody;Polyadenylation factor Clp1 antibody;Polynucleotide kinase Clp1 antibody;Polyribonucleotide 5' hydroxyl kinase Clp1 antibody;Polyribonucleotide 5''-hydroxyl-kinase Clp1 antibody;Pre mRNA cleavage complex II protein Clp1 antibody;Pre-mRNA cleavage complex II protein Clp1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double-stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Plays a key role in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex: phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Its role in tRNA splicing and maturation is required for cerebellar development. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing.