Phospho-PKC delta (Y311) Recombinant Rabbit Monoclonal Antibody [JE44-20] (HA722458)

UNIPROT #

Q05655

PROTEIN NAME

Phospho-PKC delta (Y311)

SYNONYMS

CVID9 antibody;D14Ertd420e antibody;Kinase PKC delta antibody;KPCD antibody;KPCD_HUMAN antibody;MAY 1 antibody;MAY1 antibody;MGC49908 antibody;nPKC delta antibody;nPKC-delta antibody;PCKd antibody;PKC d antibody;PKC delta antibody;PKCD antibody;PKCdelta antibody;PRKC D antibody;PRKC delta antibody;Prkcd antibody;Protein Kinase C delta antibody;Protein kinase C delta type antibody;Protein kinase C delta VIII antibody;Protein Kinase Cdelta antibody;Tyrosine protein kinase PRKCD antibody

SUBCELLULAR LOCATION

Cell membrane. Cytoplasm. Membrane. Mitochondrion. Nucleus.

FUNCTION

Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression as well as survival of several cancers, is required for oxygen radical production by NADPH oxidase and acts as positive or negative regulator in platelet functional responses. Negatively regulates B cell proliferation and also has an important function in self-antigen induced B cell tolerance induction (By similarity). Upon DNA damage, activates the promoter of the death-promoting transcription factor BCLAF1/Btf to trigger BCLAF1-mediated p53/TP53 gene transcription and apoptosis. In response to oxidative stress, interact with and activate CHUK/IKKA in the nucleus, causing the phosphorylation of p53/TP53. In the case of ER stress or DNA damage-induced apoptosis, can form a complex with the tyrosine-protein kinase ABL1 which trigger apoptosis independently of p53/TP53.