IL-1RA Recombinant Rabbit Monoclonal Antibody [JE07-58] (HA722446)

UNIPROT #

P18510

PROTEIN NAME

IL-1RA

SYNONYMS

DIRA antibody;F630041P17Rik antibody;ICIL 1RA antibody;ICIL-1RA antibody;ICIL1RA antibody;IL-1ra antibody;IL-1ra3 antibody;IL-1RN antibody;IL1 inhibitor antibody;IL1F3 antibody;IL1RA antibody;IL1RA_HUMAN antibody;IL1RN (IL1F3) antibody;IL1RN antibody;Interleukin 1 receptor antagonist antibody;Interleukin-1 receptor antagonist protein antibody;Intracellular IL 1 receptor antagonist type II antibody;Intracellular interleukin 1 receptor antagonist (icIL 1ra) antibody;IRAP antibody;MGC10430 antibody;MVCD4 antibody;Type II interleukin 1 receptor antagonist antibody

SUBCELLULAR LOCATION

Cytoplasm. Secreted.

FUNCTION

Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens. The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses, particularly in the acute phase of infection and inflammation. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.