INPP4B Recombinant Rabbit Monoclonal Antibody [JE07-42] (HA722445)

UNIPROT #

O15327

PROTEIN NAME

INPP4B

SYNONYMS

Inositol polyphosphate 4 phosphatase, type II antibody;4-bisphosphate 4-phosphatase antibody;Inositol polyphosphate 4 phosphatase type II 105kDa antibody;Inositol polyphosphate 4-phosphatase type II antibody;INP4B_HUMAN antibody;Inpp4b antibody;MGC132014 antibody;Type II inositol 3,4 bisphosphate 4 phosphatase antibody;Type II inositol-3 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Catalyzes the hydrolysis of the 4-position phosphate of phosphatidylinositol 3,4-bisphosphate, inositol 1,3,4-trisphosphate and inositol 3,4-trisphosphate. Plays a role in the late stages of macropinocytosis by dephosphorylating phosphatidylinositol 3,4-bisphosphate in membrane ruffles. The lipid phosphatase activity is critical for tumor suppressor function. Antagonizes the PI3K-AKT/PKB signaling pathway by dephosphorylating phosphoinositides and thereby modulating cell cycle progression and cell survival. INPP4B encodes the inositol polyphosphate 4-phosphatase type II, one of the enzymes involved in phosphatidylinositol signaling pathways. This enzyme removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate. There is limited data to suggest that the human type II enzyme is subject to alternative splicing, as has been established for the type I enzyme.