Phospho-SMAD2 (S465+467) Recombinant Rabbit Monoclonal Antibody [PSH05-76] (HA722443)

UNIPROT #

Q15796

PROTEIN NAME

Phospho-SMAD2 (S465+467)

SYNONYMS

Drosophila, homolog of, MADR2 antibody;hMAD-2 antibody;HsMAD2 antibody;JV18 antibody;JV18-1 antibody;JV181 antibody;MAD antibody;MAD homolog 2 antibody;MAD Related Protein 2 antibody;Mad-related protein 2 antibody;MADH2 antibody;MADR2 antibody;MGC22139 antibody;MGC34440 antibody;Mother against DPP homolog 2 antibody;Mothers against decapentaplegic homolog 2 antibody;Mothers against decapentaplegic, Drosophila, homolog of, 2 antibody;Mothers against DPP homolog 2 antibody;OTTHUMP00000163489 antibody;Sma and Mad related protein 2 antibody;Sma- and Mad-related protein 2 MAD antibody;SMAD 2 antibody;SMAD family member 2 antibody;SMAD, mothers against DPP homolog 2 antibody;SMAD2 antibody;SMAD2_HUMAN antibody

SUBCELLULAR LOCATION

Cytoplasm, Nucleus.

FUNCTION

R-SMADs are receptor-regulated SMADs. SMADs are transcription factors that transduce extracellular TGF-β superfamily ligand signaling from cell membrane bound TGF-β receptors into the nucleus where they activate transcription TGF-β target genes. R-SMADS are directly phosphorylated on their c-terminus by type 1 TGF-β receptors through their intracellular kinase domain, leading to R-SMAD activation. R-SMADS include SMAD2 and SMAD3 from the TGF-β/Activin/Nodal branch, and SMAD1, SMAD5 and SMAD8 from the BMP/GDP branch of TGF-β signaling. In response to signals by the TGF-β superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.