MFGE8 Recombinant Rabbit Monoclonal Antibody [PSH05-75] (HA722442)

UNIPROT #

Q08431

PROTEIN NAME

MFGE8

SYNONYMS

BA46 antibody;Breast epithelial antigen BA46 antibody;EDIL1 antibody;HMFG antibody;hP47 antibody;HsT19888 antibody;Lactadherin antibody;Medin antibody;MFG-E8 antibody;MFGE8 antibody;MFGM antibody;MFGM_HUMAN antibody;Milk fat globule EGF factor 8 antibody;Milk fat globule EGF factor 8 protein antibody;Milk fat globule-EGF factor 8 antibody;O acetyl disialoganglioside synthase antibody;OAcGD3S antibody;SED1 antibody;SPAG10 antibody;Sperm associated antigen 10 antibody;Sperm surface protein hP47 antibody

SUBCELLULAR LOCATION

Membrane, Secreted, Cytoplasmic vesicle, secretory vesicle, acrosome membrane.

FUNCTION

Milk fat globule-EGF factor 8 protein (Mfge8), also known as lactadherin, is a protein that in humans is encoded by the MFGE8 gene. Mfge8 is a secreted protein found in vertebrates, including mammals as well as birds. MFGE8 may function as a cell adhesion protein to connect smooth muscle to elastic fibers in arteries. An amyloid fragment of MFGE8 known as medin accumulates in the aorta with aging. MFGE8 in the vasculature of adults can induce recovery from ischemia by facilitating angiogenesis. It has been suggested that antagonizing MFGE8-induced angiogenesis could be a way of fighting cancer. MFGE8 contains a phosphatidylserine (PS) binding domain, as well as an arginine-glycine-aspartic acid motif, which enables the binding to integrins. MFGE8 binds PS, which is exposed on the surface of apoptotic cells. Opsonization of the apoptotic cells and binding to integrins on the surface of phagocytic cells, mediates the engulfment of the dead cell.