Pyrophosphatase 1 Recombinant Rabbit Monoclonal Antibody [JE64-39] (HA722437)

UNIPROT #

Q15181

PROTEIN NAME

Pyrophosphatase 1

SYNONYMS

cytosolic inorganic pyrophosphatase antibody;diphosphate phosphohydrolase antibody;inorganic diphosphatase antibody;inorganic pyrophosphatase 1 antibody;Inorganic pyrophosphatase antibody;IOPPP antibody;IPYR_HUMAN antibody;PP antibody;PP1 antibody;PPA1 antibody;PPase antibody;Pyp antibody;pyrophosphatase, inorganic, 1 antibody;Pyrophosphate phospho hydrolase antibody;Pyrophosphate phospho-hydrolase antibody;SID6-8061 antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Inorganic pyrophosphatase (or inorganic diphosphatase, PPase) is an enzyme (EC 3.6.1.1) that catalyzes the conversion of one ion of pyrophosphate to two phosphate ions. This is a highly exergonic reaction, and therefore can be coupled to unfavorable biochemical transformations in order to drive these transformations to completion. The functionality of this enzyme plays a critical role in lipid metabolism (including lipid synthesis and degradation), calcium absorption and bone formation, and DNA synthesis, as well as other biochemical transformations. Two types of inorganic diphosphatase, very different in terms of both amino acid sequence and structure, have been characterised to date: soluble and transmembrane proton-pumping pyrophosphatases (sPPases and H(+)-PPases, respectively). sPPases are ubiquitous proteins that hydrolyse pyrophosphate to release heat, whereas H+-PPases, so far unidentified in animal and fungal cells, couple the energy of PPi hydrolysis to proton movement across biological membranes.