MRPS31 Recombinant Rabbit Monoclonal Antibody [JE64-25]

Function

Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. The 28S subunit of the mammalian mitoribosome may play a crucial and characteristic role in translation initiation. This gene encodes a 28S subunit protein that has also been associated with type 1 diabetes; however, its relationship to the etiology of this disease remains to be clarified. Pseudogenes corresponding to this gene have been found on chromosomes 3 and 13.

Background References

1. Min S et al. MRPS31 loss is a key driver of mitochondrial deregulation and hepatocellular carcinoma aggressiveness. Cell Death Dis. 2021 Nov

Subcellular Location

Mitochondrion.

UNIPROT

SwissProt: Q92665 Human

SwissProt: Q61733 Mouse

SwissProt: B0BN56 Rat

Synonyms

28S ribosomal protein S31 antibody

28S ribosomal protein S31, mitochondrial antibody

Imogen 38 antibody

IMOGN38 antibody

mitochondrial antibody

MRP-S31 antibody

MRPS31 antibody

RT31_HUMAN antibody

S31mt antibody