DCAF13 Recombinant Rabbit Monoclonal Antibody [JE46-31] (HA722352)

UNIPROT #

Q9NV06

PROTEIN NAME

DCAF13

SYNONYMS

DCA13_HUMAN antibody;DCAF13 antibody;DDB1 and CUL4 associated factor 13 antibody;DDB1- and CUL4-associated factor 13 antibody;DKFZP564O0463 antibody;GM83 antibody;HSPC064 antibody;MGC126859 antibody;MGC138247 antibody;WD repeat and SOF domain-containing protein 1 antibody;WD repeats and SOF1 domain containing antibody;WDSOF1 antibody

SUBCELLULAR LOCATION

Nucleus, nucleolus.

FUNCTION

Enables estrogen receptor binding activity. Predicted to be involved in maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA). Located in several cellular components, including centrosome; cytosol; and nuclear lumen. Part of Cul4-RING E3 ubiquitin ligase complex. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. Participates in the 18S rRNA processing in growing oocytes, being essential for oocyte nonsurrounded nucleolus (NSN) to surrounded nucleolus (SN) transition.