Eph receptor B1 Recombinant Rabbit Monoclonal Antibody [JE39-46]

Function

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene. Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members.

Background References

1. Kim Y et al. Colorectal cancer-associated mutations impair EphB1 kinase function. J Biol Chem. 2023 Sep

2. Li R et al. Neddylation of EphB1 Regulates Its Activity and Associates with Liver Fibrosis. Int J Mol Sci. 2023 Feb

Subcellular Location

Cell membrane, Early endosome membrane, Cell projection, dendrite.

UNIPROT

SwissProt: P54762 Human

SwissProt: Q8CBF3 Mouse

SwissProt: P09759 Rat

Synonyms