ABCE1 Recombinant Rabbit Monoclonal Antibody [JE35-87] (HA722330)

UNIPROT #

P61221

PROTEIN NAME

ABCE1

SYNONYMS

2' 5' oligoadenylate binding protein antibody;2''-5''-oligoadenylate-binding protein antibody;2'5' oligoadenylate binding protein antibody;ABC 38 antibody;ABC38 antibody;ABCE 1 antibody;ABCE1 antibody;ABCE1_HUMAN antibody;ATP binding cassette sub family E (OABP) member 1 antibody;ATP binding cassette sub family E member 1 antibody;ATP-binding cassette sub-family E member 1 antibody;HuHP 68 antibody;HuHP68 antibody;OABP antibody;Ribonuclease 4 inhibitor antibody;Ribonuclease L (2' 5' oligoisoadenylate synthetase dependent) inhibitor antibody;Ribonuclease L (2'5' oligoisoadenylate synthetase dependent) inhibitor antibody;Ribonuclease L inhibitor antibody;RLI antibody;RNase L inhibitor antibody;RNASEL1 antibody;RNASELI antibody;RNS 4I antibody;RNS4I antibody

SUBCELLULAR LOCATION

Cytoplasm, Mitochondrion.

FUNCTION

ATP-binding cassette sub-family E member 1 (ABCE1) also known as RNase L inhibitor (RLI) is an enzyme that in humans is encoded by the ABCE1 gene. ABCE1 is an ATPase that is a member of the ATP-binding cassette (ABC) transporters superfamily and OABP subfamily. ABCE1 inhibits the action of ribonuclease L. Ribonuclease L normally binds to 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) and inhibits the interferon-regulated 2-5A/RNase L pathway, which is used by viruses. ABCE1 heterodimerize with ribonuclease L and prevents its interaction with 2-5A, antagonizing the anti-viral properties of ribonuclease L, and allow the virus to synthesize viral proteins. It has also been implicated to have an effect in tumor cell proliferation and antiapoptosis. ABCE1 is an essential and highly conserved protein that is required for both eukaryotic translation initiation as well as ribosome biogenesis. The most studied homologues are Rli1p in yeast and Pixie in Drosophila.