Cleaved PARP1 Recombinant Rabbit Monoclonal Antibody [JE00-15] (HA722218)

UNIPROT #

P09874

PROTEIN NAME

Cleaved PARP1

SYNONYMS

ADP ribosyltransferase diphtheria toxin like 1 antibody;ADP ribosyltransferase NAD(+) antibody;ADP-ribosyltransferase diphtheria toxin-like 1 antibody;ADPRT 1 antibody;ADPRT antibody;ADPRT1 antibody;APOPAIN antibody;ARTD1 antibody;NAD(+) ADP-ribosyltransferase 1 antibody;PARP antibody;PARP-1 antibody;PARP1 antibody;PARP1_HUMAN antibody;Poly [ADP-ribose] polymerase 1 (PARP-1) antibody;Poly [ADP-ribose] polymerase 1 antibody;Poly ADP ribose polymerase 1 antibody;Poly(ADP ribose) polymerase antibody;Poly[ADP-ribose] synthase 1 antibody;PPOL antibody;SCA1 antibody

SUBCELLULAR LOCATION

Nucleus.

FUNCTION

Poly (ADP-ribose) polymerase (PARP) is a family of proteins involved in a number of cellular processes such as DNA repair, genomic stability, and programmed cell death. The main role of PARP (found in the cell nucleus) is to detect and initiate an immediate cellular response to metabolic, chemical, or radiation-induced single-strand DNA breaks (SSB) by signaling the enzymatic machinery involved in the SSB repair. Once PARP detects a SSB, it binds to the DNA, undergoes a structural change, and begins the synthesis of a polymeric adenosine diphosphate ribose (poly (ADP-ribose) or PAR) chain, which acts as a signal for the other DNA-repairing enzymes. Target enzymes include DNA ligase III (LigIII), DNA polymerase beta (polβ), and scaffolding proteins such as X-ray cross-complementing gene 1 (XRCC1). After repairing, the PAR chains are degraded via Poly(ADP-ribose) glycohydrolase (PARG). PARP enzymes are essential in a number of cellular functions, including expression of inflammatory genes: PARP1 is required for the induction of ICAM-1 gene expression by cardiac myocytes and smooth muscle cells, in response to TNF.