AKR1C3 Recombinant Rabbit Monoclonal Antibody [JE36-28] (HA722198)

UNIPROT #

P42330

PROTEIN NAME

AKR1C3

SYNONYMS

17 beta HSD 5 antibody;17 beta hydroxysteroid dehydrogenase type 5 antibody;17-beta-HSD 5 antibody;17-beta-hydroxysteroid dehydrogenase type 5 antibody;2-dihydrobenzene-1 antibody;2-diol dehydrogenase antibody;20 alpha-hydroxysteroid dehydrogenase antibody;20-alpha-hydroxysteroid dehydrogenase antibody;3 alpha hydroxysteroid dehydrogenase type II antibody;3-alpha-HSD type 2 antibody;3-alpha-HSD type II antibody;3-alpha-HSD type II, brain antibody;3-alpha-hydroxysteroid dehydrogenase type 2 antibody;AK1C3_HUMAN antibody;AKR1 C3 antibody;Akr1c18 antibody;AKR1C3 antibody;Aldo keto reductase family 1 member C3 antibody;Aldo-keto reductase family 1 member C3 antibody;brain antibody;Chlordecone reductase antibody;Chlordecone reductase homolog HAKRb antibody;DD-3 antibody;DD3 antibody;DDH1 antibody;DDX antibody;Dihydrodiol dehydrogenase 3 antibody;Dihydrodiol dehydrogenase type I antibody;Dihydrodiol dehydrogenase X antibody;HA1753 antibody;HAKRB antibody;HAKRe antibody;hluPGFS antibody;HSD17B5 antibody;Indanol dehydrogenase antibody;KIAA0119 antibody;PGFS antibody;Prostaglandin F synthase antibody;Testosterone 17-beta-dehydrogenase 5 antibody;Trans-1 antibody;Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase antibody;Type IIb 3 alpha hydroxysteroid dehydrogenase antibody

SUBCELLULAR LOCATION

Cytoplasm.

FUNCTION

Aldo-keto reductase family 1 member C3 (AKR1C3), also known as 17β-hydroxysteroid dehydrogenase type 5 (17β-HSD5, HSD17B5) is a key steroidogenic enzyme that in humans is encoded by the AKR1C3 gene. This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reduction of prostaglandin D2, prostaglandin H2, and phenanthrenequinone, and the oxidation of prostaglandin F2α to prostaglandin D2. It is also capable of metabolizing estrogen and progesterone. AKR1C3 may play an important role in the development of allergic diseases such as asthma, and may also have a role in controlling cell growth and/or differentiation. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. AKR1C3 is overexpressed in prostate cancer (PCa) and is associated with the development of castration-resistant prostate cancer (CRPC). In addition, AKR1C3 overexpression may serve as a promising biomarker for prostate cancer progression.