ABL1 Recombinant Rabbit Monoclonal Antibody [PSH04-08] (HA722089)

UNIPROT #

P00519

PROTEIN NAME

ABL1

SYNONYMS

Abelson murine leukemia viral oncogene homolog 1 antibody;Abelson tyrosine protein kinase 1 antibody;Abl 1 antibody;ABL antibody;ABL proto oncogene 1 non receptor tyrosine kinase antibody;ABL1 antibody;ABL1_HUMAN antibody;bcr/abl antibody;bcr/c abl oncogene protein antibody;c ABL antibody;c abl oncogene 1 non receptor tyrosine kinase antibody;c abl oncogene 1 receptor tyrosine kinase antibody;c ABL1 antibody;JTK7 antibody;p150 antibody;Proto oncogene tyrosine protein kinase ABL1 antibody;Proto-oncogene c-Abl antibody;Tyrosine-protein kinase ABL1 antibody;v abl Abelson murine leukemia viral oncogene homolog 1 antibody;v abl antibody

SUBCELLULAR LOCATION

Cytoplasm, cytoskeleton, Nucleus, Mitochondrion; Nucleus membrane.

FUNCTION

Tyrosine-protein kinase ABL1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene (previous symbol ABL) located on chromosome 9. c-Abl is sometimes used to refer to the version of the gene found within the mammalian genome, while v-Abl refers to the viral gene, which was initially isolated from the Abelson murine leukemia virus. The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell differentiation, cell division, cell adhesion, and stress response such as DNA repair. Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene. The t(9;22) translocation results in the head-to-tail fusion of the BCR and ABL1 genes, leading to a fusion gene present in many cases of chronic myelogenous leukemia. The DNA-binding activity of the ubiquitously expressed ABL1 tyrosine kinase is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function for ABL1. The ABL1 gene is expressed as either a 6- or a 7-kb mRNA transcript, with alternatively spliced first exons spliced to the common exons 2–11.