Raptor Recombinant Rabbit Monoclonal Antibody [JE59-39] (HA722028)

UNIPROT #

Q8N122

PROTEIN NAME

Raptor

SYNONYMS

KIAA1303 antibody;KOG1 antibody;Mip1 antibody;P150 target of rapamycin (TOR) scaffold protein antibody;p150 target of rapamycin (TOR) scaffold protein containing WD repeats antibody;P150 target of rapamycin (TOR)-scaffold protein antibody;Raptor antibody;Regulatory associated protein of mTOR antibody;Regulatory associated protein of MTOR complex 1 antibody;Regulatory-associated protein of mTOR antibody;RPTOR antibody;RPTOR_HUMAN antibody

SUBCELLULAR LOCATION

Lysosome membrane, Cytoplasm, Cytoplasmic granule.

FUNCTION

RPTOR encodes part of a signaling pathway regulating cell growth which responds to nutrient and insulin levels. RPTOR is an evolutionarily conserved protein with multiple roles in the mTOR pathway. The adapter protein and mTOR kinase form a stoichiometric complex. The encoded protein also associates with eukaryotic initiation factor 4E-binding protein-1 and ribosomal protein S6 kinase. It upregulates S6 kinase, the downstream effector ribosomal protein, and it downregulates the mTOR kinase. RPTOR also has a positive role in maintaining cell size and mTOR protein expression. The association of mTOR and RPTOR is stabilized by nutrient deprivation and other conditions which suppress the mTOR pathway. Multiple transcript variants exist for this gene which encode different isoforms.