GRK6 Recombinant Rabbit Monoclonal Antibody [JE63-06]

Function

G protein-coupled Receptor Kinase 6 (GRK6) is one of 7 members of the GRK serine/threonine kinase subfamily, which are known primarily for their role in desensitizing activated G protein-coupled receptors (GPCRs) . GRKs function by phosphorylating serine/threonine residues in activated GPCRs. Upon phosphorylation these residues serve as binding sites for β-arrestin proteins, inhibiting re-activation of GPCRs by blocking their re-association with G proteins . There is evidence that GRKs can also modulate selected non-GPCR signaling pathways . For example, GRK6 has been shown to modulate the Wnt signaling pathway via phosphorylation of LRP6 , and the insulin-like growth factor signaling pathway. GRK6 may also play a role in immune system function. Investigators have found GRK6 expression is typically abundant in hematopoietic tumor cell lines, and a recent research study demonstrated that GRK6 suppression was selectively lethal for a number of myeloma tumor cell lines .

Background References

1. Mushegian A, Gurevich VV, Gurevich EV. The origin and evolution of G protein-coupled receptor kinases. PLoS One. 2012;7(3):e33806. doi: 10.1371/journal.pone.0033806. Epub 2012 Mar 19.

2. Gurevich EV, Tesmer JJ, Mushegian A, Gurevich VV. G protein-coupled receptor kinases: more than just kinases and not only for GPCRs. Pharmacol Ther. 2012 Jan;133(1):40-69.

3. Zheng H, Worrall C, Shen H, Issad T, Seregard S, Girnita A, Girnita L. Selective recruitment of G protein-coupled receptor kinases (GRKs) controls signaling of the insulin-like growth factor 1 receptor. Proc Natl Acad Sci U S A. 2012 May 1;109(18):7055-60.

Subcellular Location

Membrane.

UNIPROT

SwissProt: P43250 Human

Synonyms

FLJ32135 antibody

G protein coupled receptor kinase 6 antibody

G protein coupled receptor kinase GRK6 antibody

G protein-coupled receptor kinase 6 antibody

G protein-coupled receptor kinase GRK6 antibody

Gprk6 antibody

Grk6 antibody

GRK6_HUMAN antibody